In Seven Brides For Seven Brothers, a man named Adam comes into town looking to hurriedly find himself a wife. While in town he meets Milly, a waitress at a local restaurant. Milly and Adam rush into marriage and immediately return to Adam's home in the mountains. As soon as they get home, Adam reverts back to his true self, an ill-mannered and inconsiderate slob. Milly quickly learns that it is not only she and Adam that will be living in his home together, his six brothers also live with him.

The show is an adaption of the short story "The Sobbin' Women," by Stephen Vincent Benet, based on the ancient Roman legend of the rape of the Sabine women.